PD-1 antibody (AA 25-167)

Catalog No. ABIN5688354

This Llama Monoclonal antibody specifically detects PD-1 in FACS and ELISA. It exhibits reactivity toward Human.

Quick Overview for PD-1 antibody (AA 25-167) (ABIN5688354)

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Fragment: single-domain Antibody (sdAb)

Reactivity: Human

Host: Llama

Clonality: Monoclonal

Conjugate: This PD-1 antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA

Clone: F1-2A8

Product Details anti-PD-1 Antibody

Binding Specificity: AA 25-167

Purification: PD-1 Antibody is affinity chromatography purified via Nickel column.

Immunogen: PD-1 antibody was raised against a recombinant protein corresponding to amino acids 25 - 167 of human PD-1.

Application Details

Application Notes: PD-1 antibody can be used for detection of PD-1 by ELISA and FACS (10 μ,g/mL).

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PD-1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: PD-1 antibody should be stored in working aliquots at -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PD-1

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Alternative Name: PD-1

Background: PD-1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases.

Gene ID: 5133

NCBI Accession: NP_005009

UniProt: Q15116

Pathways: Cancer Immune Checkpoints