PD-1 antibody
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- Target See all PD-1 (PDCD1) Antibodies
- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
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Reactivity
- Human, Non-Human Primate
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This PD-1 antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)
- Specificity
- The mouse monoclonal antibody EH12.2H7 recognizes an extracellular epitope of CD279 / PD-1 (programmed cell death 1), a 55 kDa type I transmembrane protein expressed above all during T cell development, on activated T cells, activated B cells, and activated monocytes.
- Cross-Reactivity (Details)
- Human, Non-Human Primates
- Purification
- Purified by protein-A affinity chromatography.
- Purity
- > 95 % (by SDS-PAGE)
- Endotoxin Level
- Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
- Immunogen
- recombinant human CD279
- Clone
- EH12-2H7
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product PDCD1 Primary Antibody
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anti-Programmed Cell Death 1 (PDCD1) (AA 201-288) antibody
PDCD1 Reactivity: Human, Mouse, Rat FACS, WB, ELISA, IHC (p), IHC (fro), IF (p), IF (cc) Host: Rabbit Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 41-132) antibodyPDCD1 Reactivity: Human WB, ELISA, IHC (p), ICC, IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 192-288) antibodyPDCD1 Reactivity: Human FACS, WB, ELISA Host: Mouse Monoclonal 8G5B12 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 192-288) antibodyPDCD1 Reactivity: Human FACS, WB, ELISA Host: Mouse Monoclonal 3B3D9 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 21-170) antibodyPDCD1 Reactivity: Human FACS, WB, IHC, ELISA, ICC, Neut Host: Mouse Monoclonal 3E12A10 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 21-170) antibodyPDCD1 Reactivity: Human FACS, WB, IHC, ELISA, ICC, Neut Host: Mouse Monoclonal 1D6F6 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 21-170) antibodyPDCD1 Reactivity: Human WB, IHC, ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) antibodyPDCD1 Reactivity: Human IHC, ELISA, StM, Coat Host: Mouse Monoclonal PDCD1-2720 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 1-288) antibodyPDCD1 Reactivity: Human WB Host: Mouse Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 41-132) antibodyPDCD1 Reactivity: Human WB, IHC, IP, ICC Host: Mouse Monoclonal C1 unconjugated
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- Application Notes
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Functional application: Blocking.
Flow cytometry: Recommended dilution: 1-4 μg/mL - Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4
- Preservative
- Azide free
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Do not freeze.
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- Target
- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
- Alternative Name
- CD279 / PD-1 (PDCD1 Products)
- Synonyms
- CD279 antibody, PD-1 antibody, PD1 antibody, SLEB2 antibody, hPD-1 antibody, hPD-l antibody, Ly101 antibody, Pdc1 antibody, programmed cell death 1 antibody, PDCD1 antibody, Pdcd1 antibody
- Background
- Programmed cell death 1,CD279 / PD-1 (programmed cell death 1), a transmembrane protein of CD28/CTLA-4 family. It is expressed inducibly mainly on activated T, B, and myeloid cells and plays a role in maintaining peripheral self-tolerance. Binding to its ligands CD273 and CD274 is associated with inhibition of T cell proliferation and induction of their anergy. It is also expressed during thymic development. Some variants of CD279 are associated with susceptibility to systemic lupus erythematosus, type 1 diabetes, and rheumatoid arthritis.,PDCD1, PD1, SLEB2
- Gene ID
- 5133
- UniProt
- Q15116
- Pathways
- Cancer Immune Checkpoints
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