STXBP1 antibody (pSer515)

Catalog No. ABIN5688903

This Rabbit Polyclonal antibody specifically detects STXBP1 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Chicken and Xenopus laevis.

Quick Overview for STXBP1 antibody (pSer515) (ABIN5688903)

Target: STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Chicken, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STXBP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-STXBP1 Antibody

Binding Specificity: pSer515

Purification: Affinity Purified

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser515 of Munc-18.

Application Details

Application Notes: The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, chicken, human, mouse, non-human primates and Xenopus based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 100 μLin 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.

Storage: -20 °C

Storage Comment: Munc-18 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Target Details for STXBP1

Target: STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

Alternative Name: Munc-18

Background: Munc-18 ( mammalian homologue of Unc-18) is a protein that is thought to be involved in regulating exocytosis due, at least in part, to it ability to bind syntaxin (Ciufo et al., 2005). Munc18-1 is a neuron-specific member of the Sec1/Munc18 protein family that binds to syntaxin1A and is thought to stabilize the complex (Liu et al., 2004). The function of Munc-18 is thought to be regulated by PKC phosphorylation of Ser515 on the Munc-18 protein (Sassa et al., 1996).

Molecular Weight: 65 kDa

Gene ID: 81804

UniProt: Q62753

Pathways: Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport