MAP2K5 antibody (AA 311-315)

Catalog No. ABIN5689204

The Rabbit Polyclonal anti-MAP2K5 antibody has been validated for WB. It is suitable to detect MAP2K5 in samples from Human, Mouse and Rat.

Quick Overview for MAP2K5 antibody (AA 311-315) (ABIN5689204)

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP2K5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAP2K5 Antibody

Binding Specificity: AA 311-315

Specificity: This antibody detects endogenous level of total MEK5 protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide

Immunogen: MEK5 antibody was raised against a peptide sequence around aa. 311-315 (K-T-Y-V-G ) derived from Rat MEK5.

Application Details

Application Notes: Western Blot: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store antibody at -20°C for up to one year.

Target Details for MAP2K5

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Alternative Name: MEK5

Background: A family of protein kinases located upstream of the MAP kinases andresponsible for their activation has been identified. The prototype member ofthis family, designated MAP kinase kinase, or MEK-1, specifically phospho-rylates the MAP kinase regulatory threonine and tyrosine residues present inthe Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resem-bles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to acti-vate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activatesboth p38 and JNK MAP kinases. MEK-5 appears to specifically phosphory-late ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7)phosphorylates and activates the JNK signal transduction pathway.

Molecular Weight: 49 kDa

Gene ID: 29568

NCBI Accession: NP_001029159

UniProt: Q62862

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway