TAZ antibody (AA 386-390)

Catalog No. ABIN5689355

This anti-TAZ antibody is a Rabbit Polyclonal antibody detecting TAZ in WB. Suitable for Human, Mouse and Rat.

Quick Overview for TAZ antibody (AA 386-390) (ABIN5689355)

Target: TAZ (Tafazzin (TAZ))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAZ antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TAZ Antibody

Binding Specificity: AA 386-390

Specificity: This antibody detects endogenous level of total TAZ protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: TAZ antibody was raised against a peptide sequence around aa.386~390 (V-E-S-A-L) derived from Human TAZ.

Application Details

Application Notes: Western Blot: 1:500~1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store antibody at -20°C for up to one year.

Target Details for TAZ

Target: TAZ (Tafazzin (TAZ))

Alternative Name: TAZ

Background: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

Molecular Weight: 49 kDa

Gene ID: 25937

NCBI Accession: NP_001161750

UniProt: Q9GZV5