BCL2L1 antibody (AA 60-64)

Catalog No. ABIN5689429

The Rabbit Polyclonal anti-BCL2L1 antibody has been validated for WB. It is suitable to detect BCL2L1 in samples from Human, Mouse and Rat.

Quick Overview for BCL2L1 antibody (AA 60-64) (ABIN5689429)

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL2L1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BCL2L1 Antibody

Binding Specificity: AA 60-64

Specificity: This antibody detects endogenous level of total BCL-XL protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: BCL-XL (Ab-62) antibody was raised against a peptide sequence around aa.60~64 (A-D-S-P-A) derived from human BCL-XL .

Application Details

Application Notes: Western Blot: 1:500~1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store antibody at -20°C for up to one year.

Target Details for BCL2L1

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Alternative Name: BCL XL

Background: Potent inhibitor of cell death. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases By similarity. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.

Molecular Weight: 30 kDa

Gene ID: 598

NCBI Accession: NP_612815

UniProt: Q07817

Pathways: Apoptosis, Negative Regulation of intrinsic apoptotic Signaling