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ABL1/2 antibody (AA 391-395, AA 427-231)
ABL1/ABL2
Reactivity: Human, Mouse
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-ABL1/2 Antibody
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Target
See all ABL1/2 (ABL1/ABL2) Antibodies
ABL1/2 (ABL1/ABL2)
(Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2))
Binding Specificity
All epitopes for ABL1/2 antibodies
AA 391-395, AA 427-231
Reactivity
All reactivities for ABL1/2 antibodies
Human, Mouse
Host
All hosts for ABL1/2 antibodies
Rabbit
Clonality
All clonalities for ABL1/2 antibodies
Polyclonal
Conjugate
All conjugates for ABL1/2 antibodies
This ABL1/2 antibody is un-conjugated
Application
All applications for ABL1/2 antibodies
Western Blotting (WB)
Specificity
This antibody detects endogenous levels of total ABL1/2 protein.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
ABL1/2 (Ab-393/429) antibody was raised against a peptide sequence around aa.391~395/427~431 (D-T-Y-T-A) derived from ABL1/2 .
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Application Details
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Application Notes
Western Blot: 1:500~1:1000
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store antibody at -20°C for up to one year.
Target Details for ABL1/2
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Target
ABL1/2 (ABL1/ABL2)
(Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2))
Alternative Name
ABL1 / 2 (ABL1/ABL2 Products )
Synonyms
CABL antibody, ABLL antibody, cb272 antibody, ABL proto-oncogene 2, non-receptor tyrosine kinase antibody, c-abl oncogene 2, non-receptor tyrosine kinase antibody, ABL2 antibody, abl2 antibody
Background
Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
Molecular Weight
135, 210 kDa
Gene ID
25, 27
NCBI Accession
NP_005148 , NP_001129472
UniProt
P00519 , P42684
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