SKIV2L antibody (AA 260-310)

Catalog No. ABIN5689978

The Rabbit Polyclonal anti-SKIV2L antibody is suitable to detect SKIV2L in samples from Human and Mouse. It has been validated for ELISA, WB, IF and IHC (p).

Quick Overview for SKIV2L antibody (AA 260-310) (ABIN5689978)

Target: SKIV2L (Superkiller Viralicidic Activity 2-Like (SKIV2L))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SKIV2L antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SKIV2L Antibody

Binding Specificity: AA 260-310

Specificity: GPRASP1 antibody is human and mouse reactive. This antibody is predicted to not cross-react with GPRASP2.

Purification: GPRASP1 antibody is affinity chromatography purified via peptide column.

Immunogen: GPRASP1 antibody was raised against a 15 amino acid peptide near the amino terminus of human GPRASP1.

The immunogen is located within amino acids 260 - 310 of GPRASP1.

Isotype: IgG

Application Details

Application Notes: GPRASP1 antibody can be used for detection of GPRASP1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: GPRASP1 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: GPRASP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for SKIV2L

Target: SKIV2L (Superkiller Viralicidic Activity 2-Like (SKIV2L))

Alternative Name: SKI2W

Background: The G protein-coupled receptor associated sorting protein 1 (GPRASP1) is a member of the GPRASP family and is thought to modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors (1,2). GPRASP1 interacts with receptors such as the D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CNR1) and targets these proteins for degradation in lysosomes (2). Recently, it has been shown that increased GPRASP1 levels may act as a potential biomarker for breast cancer (3).

Molecular Weight: Predicted: 153 kDa

Observed: 150 kDa

Gene ID: 9737

NCBI Accession: NP_001171656

UniProt: Q5JY77