Neuroligin 2 antibody (AA 630-680)

Catalog No. ABIN5690079

Product Details anti-Neuroligin 2 Antibody

Target: Neuroligin 2 (NLGN2)

Binding Specificity: AA 630-680

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuroligin 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: NLGN2 antibody is human, mouse and rat reactive. At least two isoforms are known to exist, this antibody will detect both isoforms. NLGN2 antibody is predicted to not cross-react with other members of the NLGN protein family.

Purification: NLGN2 antibody is affinity chromatography purified via peptide column.

Immunogen: NLGN2 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human NLGN2.

The immunogen is located within amino acids 630 - 680 of NLGN2.

Isotype: IgG

Application Details

Application Notes: NLGN2 antibody can be used for detection of NLGN2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: NLGN2 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: NLGN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for Neuroligin 2

Target: Neuroligin 2 (NLGN2)

Alternative Name: NLGN2 (NLGN2 Products)

Background: Neuroligin 2 (NLGN2) is a member of a family of neuronal cell surface proteins that localize to the post-synaptic membrane (1,2). Neuroligins are thought to act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses (2). NLGN2 has been shown to control perisomatic inhibitory synapse maturation together with gephyrin and collybistin, thereby regulating GABA receptor clustering on neurons (3,4). NLGN2 also exhibits differential functions at different types of inhibitory synapses on the same postsynaptic neuron (5).

Molecular Weight: Predicted: 92, 99 kDa

Observed: 80, 97 kDa

Gene ID: 57555

NCBI Accession: NP_065846

UniProt: Q8NFZ4

Pathways: Cell-Cell Junction Organization, Synaptic Membrane