LTB antibody (AA 31-221)

Catalog No. ABIN5690619

This Rat Monoclonal antibody specifically detects LTB in Func and FACS. It exhibits reactivity toward Mouse.

Quick Overview for LTB antibody (AA 31-221) (ABIN5690619)

Target: LTB (Lymphotoxin beta (TNF Superfamily, Member 3) (LTB))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This LTB antibody is un-conjugated

Application: Functional Studies (Func), Flow Cytometry (FACS)

Clone: 4H8 WH2

Product Details anti-LTB Antibody

Binding Specificity: AA 31-221

Specificity: Recognizes mouse LTbetaR.

Purity: > 95% (SDS-PAGE)

Immunogen: Recombinant mouse LTbetaR (cysteine-rich region/aa 31-221).

Isotype: IgG2a

Application Details

Application Notes: Functional Application: Agonist inducing BAFF, chemokines and integrins in vitro and in vivo.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. In PBS containing 10 % glycerol.

Storage: -20 °C

Storage Comment: Stable for at least 1 year after receipt when stored at -20°C.

Target Details for LTB

Target: LTB (Lymphotoxin beta (TNF Superfamily, Member 3) (LTB))

Alternative Name: LTbeta

Background: The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

Gene ID: 17000

UniProt: P50284

Pathways: NF-kappaB Signaling