Bestrophin 1 antibody (DyLight 488)

Catalog No. ABIN7354625

This anti-Bestrophin 1 antibody is a Rabbit Polyclonal antibody detecting Bestrophin 1 in FACS. Suitable for Human.

Quick Overview for Bestrophin 1 antibody (DyLight 488) (ABIN7354625)

Target: Bestrophin 1 (BEST1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Bestrophin 1 antibody is conjugated to DyLight 488

Application: Flow Cytometry (FACS)

Product Details anti-Bestrophin 1 Antibody (DyLight 488)

Purpose: Anti-Human Bestrophin DyLight® 488 conjugated BEST1 Antibody

Sequence: RFIYRLALTE EQQLMFEKLT LYCD

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Human Bestrophin DyLight® 488 conjugated BEST1 Antibody -Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Bestrophin, which shares 62.5% amino acid (aa) sequence identity with mouse Bestrophin.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells1. "Entrez Gene: BEST1 bestrophin 1". 2. Johnson AA, Guziewicz KE, Lee CJ, Kalathur RC, Pulido JS, Marmorstein LY, Marmorstein AD (January 2017). "Bestrophin 1 and retinal disease". review. Progress in Retinal and Eye Research. 58: 45-69.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Target Details for Bestrophin 1

Target: Bestrophin 1 (BEST1)

Alternative Name: BEST1

Background:

Synonyms: Bestrophin-1, TU15B, Vitelliform macular dystrophy protein 2, BEST1, VMD2

Tissue Specificity: Predominantly expressed in the basolateral membrane of the retinal pigment epithelium.

Background: Bestrophin-1 (Best1) is a protein that, in humans, is encoded by the BEST1 gene. This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.

Molecular Weight: 39 kDa

Gene ID: 7439

UniProt: O76090