Bestrophin 1 antibody (AA 376-585)

Catalog No. ABIN6137534

This Rabbit Polyclonal antibody specifically detects Bestrophin 1 in WB. It exhibits reactivity toward Human.

Quick Overview for Bestrophin 1 antibody (AA 376-585) (ABIN6137534)

Target: Bestrophin 1 (BEST1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Bestrophin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Bestrophin 1 Antibody

Binding Specificity: AA 376-585

Sequence: QPNQEDEEDA HAGIIGRFLG LQSHDHHPPR ANSRTKLLWP KRESLLHEGL PKNHKAAKQN VRGQEDNKAW KLKAVDAFKS APLYQRPGYY SAPQTPLSPT PMFFPLEPSA PSKLHSVTGI DTKDKSLKTV SSGAKKSFEL LSESDGALME HPEVSQVRRK TVEFNLTDMP EIPENHLKEP LEQSPTNIHT TLKDHMDPYW ALENRDEAHS

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 376-585 of human BEST1 (NP_004174.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Bestrophin 1

Target: Bestrophin 1 (BEST1)

Alternative Name: BEST1

Background: This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.,BEST1,ARB,BEST,BMD,RP50,TU15B,VMD2,Cell Biology & Developmental Biology,Cell Adhesion,Neuroscience,BEST1

Molecular Weight: 57 kDa/67 kDa/69 kDa

Gene ID: 7439

UniProt: O76090