IL17C antibody (AA 19-197)

Catalog No. ABIN5692880

This anti-IL17C antibody is a Rabbit Polyclonal antibody detecting IL17C in WB and ELISA. Suitable for Human and Mouse.

Quick Overview for IL17C antibody (AA 19-197) (ABIN5692880)

Target: IL17C (Interleukin 17C (IL17C))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL17C antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-IL17C Antibody

Binding Specificity: AA 19-197

Purpose: Anti-IL17C Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-IL17C Antibody Picoband® (ABIN5692880). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Immunogen: E. coli-derived human IL17C recombinant protein (Position: H19-V197).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL
ELISA (Cap), 1-5 μg/mL
1. Chang, S. H., Reynolds, J. M., Pappu, B. P., Chen, G., Martinez, G. J., Dong, C. Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E.Immunity 35: 611-621, 2011. 2. Conti, H. R., Whibley, N., Coleman, B. M., Garg, A. V., Jaycox, J. R., Gaffen, S. L. Signaling through IL-17C/IL-17RE is dispensable for immunity to systemic, oral and cutaneous candidiasis. PLoS One 10: e0122807, 2015.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for IL17C

Target: IL17C (Interleukin 17C (IL17C))

Alternative Name: IL17C

Background:

Synonyms: Interleukin-17C, IL-17C, Cytokine CX2, IL17C, UNQ561/PRO1122

Tissue Specificity: Found in serum and urine.

Background: IL17C, also known as CX2, is a protein that in humans is encoded by the IL17C gene. IL17C is mapped to 16q24.3. The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. IL17C is an essential autocrine cytokine regulating innate epithelial immune responses. It also plays an important role in the pathogenesis of inflammatory arthritis.

Molecular Weight: 29 kDa

Gene ID: 27189

UniProt: Q9P0M4

Pathways: Cellular Response to Molecule of Bacterial Origin