IL17C antibody (AA 101-197)

Catalog No. ABIN747983

Product Details anti-IL17C Antibody

Target: IL17C (Interleukin 17C (IL17C))

Binding Specificity: AA 101-197

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL17C antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IL-17C

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-IL17C antibody (ABIN747983)

Huang, Meng, Hong, Lin, Jin, Dong: "IL-17C is required for lethal inflammation during systemic fungal infection." in: Cellular & molecular immunology, Vol. 13, Issue 4, pp. 474-83, (2017) (PubMed).

Huang, Yuan, Zhu, Yin, Hong, Dong, Jin, Dong: "IL-17C/IL-17RE Augments T Cell Function in Autoimmune Hepatitis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 198, Issue 2, pp. 669-680, (2016) (PubMed).

Target Details for IL17C

Target: IL17C (Interleukin 17C (IL17C))

Alternative Name: IL-17C (IL17C Products)

Synonyms: IL17C antibody, il17-3 antibody, CX2 antibody, IL-17C antibody, IL-21 antibody, interleukin 17C antibody, interleukin 17c antibody, IL17C antibody, il17c antibody, Il17c antibody

Background:

Synonyms: CX2, IL-17C, Interleukin-17C, Cytokine CX2, IL17C, UNQ561/PRO1122

Background: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.

Gene ID: 27189

UniProt: Q9P0M4

Pathways: Cellular Response to Molecule of Bacterial Origin