Neuromedin U antibody

Catalog No. ABIN5692905

This Rabbit Polyclonal antibody specifically detects Neuromedin U in WB and IHC. It exhibits reactivity toward Rat and Mouse.

Quick Overview for Neuromedin U antibody (ABIN5692905)

Target: Neuromedin U (NMU)

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuromedin U antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Neuromedin U Antibody

Purpose: Anti-NMU Antibody

Sequence: FRVDEEFQSP FASQSRGYFL FRPRN

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: Human

Characteristics: Anti-NMU Antibody (ABIN5692905). Tested in WB applications. This antibody reacts with Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human NMU, which shares 64% and 56% amino acid (aa) sequence identity with mouse and rat NMU, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for Neuromedin U

Target: Neuromedin U (NMU)

Alternative Name: NMU

Background:

Synonyms: Neuromedin-U, Neuromedin-U-25, NmU-25, NMU

Tissue Specificity: Expressed throughout the enteric nervous system with highest levels being found in the jejunum.

Background: Neuromedin U (NMU) is a neuropeptide with potent activity on smooth muscle, which was isolated first from porcine spinal cord and later from other species. It is a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide.

Molecular Weight: 26 kDa

Gene ID: 10874

UniProt: P48645

Pathways: Feeding Behaviour, Photoperiodism