IL-27 antibody (AA 29-234)

Catalog No. ABIN5692968

This Rabbit Polyclonal antibody specifically detects IL-27 in WB and ELISA. It exhibits reactivity toward Rat.

Quick Overview for IL-27 antibody (AA 29-234) (ABIN5692968)

Target: IL-27 (IL27) (Interleukin 27 (IL27))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-27 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-IL-27 Antibody

Binding Specificity: AA 29-234

Purpose: Anti-IL27 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-IL27 Antibody Picoband® (ABIN5692968). Tested in ELISA, WB applications. This antibody reacts with Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Immunogen: E. coli-derived mouse IL27 recombinant protein (Position: F29-S234).

Isotype: IgG

Application Details

Application Notes: Western blot,0.1-0.5 μg/mL
ELISA,0.1-0.5 μg/mL
1. Meka, Rakeshchandra R., Venkatesha, Shivaprasad H., Dudics, Steven, Acharya, Bodhraj, Moudgil, Kamal D. "IL-27-induced modulation of autoimmunity and its therapeutic potential". Autoimmunity Reviews. 14 (12): 1131-1141. 2. Yoshimoto, Takayuki, Chiba, Yukino, Furusawa, Jun-Ichi, Xu, Mingli, Tsunoda, Ren, Higuchi, Kaname, Mizoguchi, Izuru (2015-09-01). "Potential clinical application of interleukin-27 as an antitumor agent". Cancer Science. 106 (9): 1103-1110.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for IL-27

Target: IL-27 (IL27) (Interleukin 27 (IL27))

Alternative Name: Il27

Background:

Synonyms: Interleukin-27 subunit alpha, IL-27 subunit alpha, IL-27-A, IL27-A, p28, Il27, Il27a

Tissue Specificity: Expressed in macrophages and dendritic cells.

Background: Interleukin 27 (IL-27) is a member of the IL-12 cytokine family. The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4 (+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4 (+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).

Molecular Weight: 29 kDa

Gene ID: 246779

UniProt: Q8K3I6