LPAR6 antibody

Catalog No. ABIN5693041

The Rabbit Polyclonal anti-LPAR6 antibody has been validated for WB and FACS. It is suitable to detect LPAR6 in samples from Human.

Quick Overview for LPAR6 antibody (ABIN5693041)

Target: LPAR6 (Lysophosphatidic Acid Receptor 6 (LPAR6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LPAR6 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-LPAR6 Antibody

Purpose: Anti-P2RY5/LPAR6 Antibody Picoband®

Sequence: DTIQNSIKMK NWSVRRSDFR FSEVHGAENF IQHNLQTLK

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-P2RY5/LPAR6 Antibody Picoband® (ABIN5693041). Tested in Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human P2RY5, which shares 92.3% and 89.7% amino acid (aa) sequence identity with mouse and rat P2RY5, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells1. Nahum, S., Morice-Picard, F., Taieb, A., Sprecher, E. A novel mutation in LPAR6 causes autosomal recessive hypotrichosis of the scalp. Clin. Exp. Derm. 36: 188-194, 2010. 2. Shimomura, Y., Wajid, M., Ishii, Y., Shapiro, L., Petukhova, L., Gordon, D., Christiano, A. M.Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair. Nature Genet. 40: 335-339, 2008.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for LPAR6

Target: LPAR6 (Lysophosphatidic Acid Receptor 6 (LPAR6))

Alternative Name: LPAR6

Background:

Synonyms: Lysophosphatidic acid receptor 6, LPA receptor 6, LPA-6, Oleoyl-L-alpha-lysophosphatidic acid receptor, P2Y purinoceptor 5, P2Y5, Purinergic receptor 5, RB intron encoded G-protein coupled receptor, LPAR6, P2RY5

Tissue Specificity: Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes.

Background: Lysophosphatidic acid receptor 6 also known as LPA6, P2RY5, and GPR87, is a protein that in humans is encoded by the LPAR6 gene. The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants.

Molecular Weight: 39 kDa

Gene ID: 10161

UniProt: P43657