MPZ antibody (AA 30-153)

Catalog No. ABIN5693047

The Rabbit Polyclonal anti-MPZ antibody has been validated for WB and ELISA. It is suitable to detect MPZ in samples from Human, Rat and Mouse.

Quick Overview for MPZ antibody (AA 30-153) (ABIN5693047)

Target: MPZ (Myelin Protein Zero (MPZ))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MPZ antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MPZ Antibody

Binding Specificity: AA 30-153

Purpose: Anti-Myelin Protein Zero/MPZ Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Myelin Protein Zero/MPZ Antibody Picoband® (ABIN5693047). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Immunogen: E. coli-derived human Myelin Protein Zero recombinant protein (Position: I30-R153).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL
ELISA, 0.1-0.5 μg/mL
1. Lemke G, Axel R (March 1985). "Isolation and sequence of a cDNA encoding the major structural protein of peripheral myelin". Cell. 40 (3): 501-8. 2. Sakamoto Y, Kitamura K, Yoshimura K, Nishijima T, Uyemura K (March 1987). "Complete amino acid sequence of P0 protein in bovine peripheral nerve myelin". J. Biol. Chem. 262 (9): 4208-14.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for MPZ

Target: MPZ (Myelin Protein Zero (MPZ))

Alternative Name: MPZ

Background:

Synonyms: Myelin protein P0, Myelin peripheral protein, MPP, Myelin protein zero, MPZ

Tissue Specificity: Found only in peripheral nervous system Schwann cells.

Background: Myelin protein zero (P0, MPZ) is a glycoprotein which in humans is encoded by the MPZ gene. This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.

Molecular Weight: 28 kDa

Gene ID: 4359

UniProt: P25189