CASR antibody (AA 926-1078) (DyLight 488)

Catalog No. ABIN5693097

This Mouse Monoclonal antibody specifically detects CASR in FACS. It exhibits reactivity toward Human.

Quick Overview for CASR antibody (AA 926-1078) (DyLight 488) (ABIN5693097)

Target: CASR (Calcium-Sensing Receptor (CASR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CASR antibody is conjugated to DyLight 488

Application: Flow Cytometry (FACS)

Clone: 11E9

Product Details anti-CASR Antibody (DyLight 488)

Binding Specificity: AA 926-1078

Purpose: Anti-Human CASR DyLight® 488 conjugated Antibody(monoclonal, 11E9)

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Human CASR DyLight® 488 conjugated Antibody (monoclonal, 11E9) (ABIN5693096)-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

Immunogen: E. coli-derived human CASR recombinant protein (Position: Q926-S1078). Human CASR shares 80.5% and 78.6% amino acid (aa) sequence identity with mouse and rat CASR, respectively.

Isotype: IgG2b

Application Details

Application Notes: Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells1. Coburn JW, Elangovan L, Goodman WG, Fraza111 JM (Dec 1999). "Calcium-sensing receptor and calcimimetic agents". Kidney International. Supplement 73: S52-8. 2. D'Souza-Li L (Aug 2006). "The calcium-sensing receptor and related diseases". Arquivos Brasileiros De Endocrinologia E Metabologia 50 (4): 628-39. 3. Pidasheva S, Canaff L, Simonds WF, Marx SJ, Hendy GN (Jun 2005). "Impaired cotranslational processing of the calcium-sensing receptor due to signal peptide missense mutations in familial hypocalciuric hypercalcemia". Human Molecular Genetics 14 (12): 1679-90.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Target Details for CASR

Target: CASR (Calcium-Sensing Receptor (CASR))

Alternative Name: CASR

Background:

Synonyms: Extracellular calcium-sensing receptor, CaR

Tissue Specificity: Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.

Background: The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

Molecular Weight: 39 kDa

Gene ID: 846

UniProt: P41180

Pathways: Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis