Topoisomerase I antibody (AA 1-100)

Catalog No. ABIN5697520

This Rabbit Polyclonal antibody specifically detects Topoisomerase I in WB, ELISA, IHC and IP. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Topoisomerase I antibody (AA 1-100) (ABIN5697520)

Target: Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Topoisomerase I antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-Topoisomerase I Antibody

Binding Specificity: AA 1-100

Purpose: TOP1 antibody

Immunogen:

Immunogen sequence: peptide(1-100aa)

Immunogen: topoisomerase (DNA) I

Isotype: IgG

Application Details

Application Notes: WB : 1:200-1:2000 IP : 1:200-1:2000 IHC : 1:20-1:200 IF : 1:50-1:500

Comment:

L02 cells were subjected to SDS PAGE followed by western blot with FNab08865(TOP1 antibody) at dilution of 1:500

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for Topoisomerase I

Target: Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))

Alternative Name: TOP1

Background:

Synonyms: DNA topoisomerase 1|DNA topoisomerase I|TOP1

Background: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.

Molecular Weight: 90 kDa

Gene ID: 7150

UniProt: P11387

Pathways: Caspase Cascade in Apoptosis, Stem Cell Maintenance