SMG5 antibody

Catalog No. ABIN5699364

This anti-SMG5 antibody is a Rabbit Polyclonal antibody detecting SMG5 in WB, ELISA and IHC. Suitable for Human, Mouse and Rat.

Quick Overview for SMG5 antibody (ABIN5699364)

Target: SMG5 (Smg-5 Homolog, Nonsense Mediated mRNA Decay Factor (SMG5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMG5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-SMG5 Antibody

Purpose: SMG5 antibody

Immunogen: Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

HeLa cells were subjected to SDS PAGE followed by western blot with FNab08025(SMG5 antibody) at dilution of 1:400

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SMG5

Target: SMG5 (Smg-5 Homolog, Nonsense Mediated mRNA Decay Factor (SMG5))

Alternative Name: SMG5

Background:

Synonyms: Nonsense-mediated mRNA decay factor SMG5|EST1-like protein B|LPTS-RP1|LPTS-interacting protein|SMG-5 homolog (hSMG-5)|SMG5|EST1B|KIAA1089

Background: Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A(PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity.

Gene ID: 23381

UniProt: Q9UPR3