ABAT antibody

Catalog No. ABIN5699780

The Rabbit Polyclonal anti-ABAT antibody has been validated for WB, IHC, ELISA and IP. It is suitable to detect ABAT in samples from Human, Mouse and Rat.

Quick Overview for ABAT antibody (ABIN5699780)

Target: ABAT (4-Aminobutyrate Aminotransferase (ABAT))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABAT antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Product Details anti-ABAT Antibody

Immunogen: 4-aminobutyrate aminotransferase

Isotype: IgG

Application Details

Application Notes: WB : 1:200-1:2000,IHC:1:20-1:200,IP:1:200-1:2000

Comment:

human liver tissue were subjected to SDS PAGE followed by western blot with FNab00026(ABAT antibody) at dilution of 1:300

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for ABAT

Target: ABAT (4-Aminobutyrate Aminotransferase (ABAT))

Alternative Name: ABAT

Background: Synonyms:ABAT, FLJ17813, GABA aminotransferase, GABA AT, GABA T, GABA transaminase, GABAT, L AIBAT Background:4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95 % similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

Molecular Weight: 55kDa

Gene ID: 18

UniProt: P80404

Pathways: Monocarboxylic Acid Catabolic Process