ADAR antibody

Catalog No. ABIN5699808

This anti-ADAR antibody is a Rabbit Polyclonal antibody detecting ADAR in WB, IHC, ELISA, IF and IP. Suitable for Human, Mouse, Rat and Pig.

Quick Overview for ADAR antibody (ABIN5699808)

Target: ADAR (Adenosine Deaminase, RNA-Specific (ADAR))

Reactivity: Human, Mouse, Rat, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-ADAR Antibody

Purpose: ADAR antibody

Immunogen:

Immunogen sequence: Peptide

Immunogen: adenosine deaminase, RNA-specific

Isotype: IgG

Application Details

Application Notes: WB :1:500-1:5000,IHC:1:20-1:200,IP:1:200-1:2000,IF:1:20-1:200

Comment:

HeLa cells were subjected to SDS PAGE followed by western blot with FNab00150( ADAR1 Antibody) at dilution of 1:1000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for ADAR

Target: ADAR (Adenosine Deaminase, RNA-Specific (ADAR))

Alternative Name: ADAR

Background:

Synonyms: Double-stranded RNA-specific adenosine deaminase (DRADA)|136 kDa double-stranded RNA-binding protein (p136)|Interferon-inducible protein 4 (IFI-4)|K88DSRBP|ADAR|ADAR1|DSRAD|G1P1|IFI4

Background: ADAR1 is also named as ADAR1, DSRAD, G1P1, IFI4. It convert selected adenosine residues into inosine in substrate RNAs containing a relatively short dsRNA region(PMID:15556947). The human ADAR1 gene specifies two size forms of RNA-specific adenosine deaminase, an interferon(IFN) inducible ?150 kDa protein and a constitutively expressed N-terminally truncated ?110 kDa protein, encoded by transcripts with alternative exon 1 structures that initiate from different promoters(PMID:11111054). It has 5 isoforms produced by alternative promoter usage and alternative splicing. Defects in ADAR are a cause of dyschromatosis symmetrical hereditaria(DSH).ADAR1 can form respective homodimers, and this association is essential for its enzymatic activities(PMID:17428802).

Molecular Weight: 136kDa,observed 110kDa

UniProt: P55265

Pathways: Protein targeting to Nucleus