ADAR antibody
Quick Overview for ADAR antibody (ABIN5699808)
Target
See all ADAR AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Immunogen
- adenosine deaminase, RNA-specific
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Isotype
- IgG
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Application Notes
- WB :1:500-1:5000,IHC:1:20-1:200,IP:1:200-1:2000,IF:1:20-1:200
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Comment
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HeLa cells were subjected to SDS PAGE followed by western blot with FNab00150( ADAR1 Antibody) at dilution of 1:1000
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Restrictions
- For Research Use only
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handling Advice
- Avoid repeated freeze / thaw cycles.
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Storage
- -20 °C
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Expiry Date
- 12 months
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- ADAR (Adenosine Deaminase, RNA-Specific (ADAR))
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Alternative Name
- ADAR1
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Background
- Synonyms:ADAR, ADAR1, adenosine deaminase, RNA, DRADA, DSH, DSRAD, G1P1, IFI 4, IFI4, Interferon inducible protein 4, K88dsRBP, p136 Background:ADAR1 is also named as ADAR1, DSRAD, G1P1, IFI4. It convert selected adenosine residues into inosine in substrate RNAs containing a relatively short dsRNA region(PMID:15556947). The human ADAR1 gene specifies two size forms of RNA-specific adenosine deaminase, an interferon(IFN) inducible ?150 kDa protein and a constitutively expressed N-terminally truncated ?110 kDa protein, encoded by transcripts with alternative exon 1 structures that initiate from different promoters(PMID:11111054). It has 5 isoforms produced by alternative promoter usage and alternative splicing. Defects in ADAR are a cause of dyschromatosis symmetrical hereditaria(DSH).ADAR1 can form respective homodimers, and this association is essential for its enzymatic activities(PMID:17428802).
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Molecular Weight
- 136kDa,observed 110kDa
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UniProt
- P55265
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Pathways
- Protein targeting to Nucleus
Target
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