TXK antibody

Catalog No. ABIN5703141

This anti-TXK antibody is a Rabbit Polyclonal antibody detecting TXK in ELISA, IHC and IF. Suitable for Human.

Quick Overview for TXK antibody (ABIN5703141)

Target: TXK (TXK tyrosine Kinase (TXK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXK antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-TXK Antibody

Immunogen: TXK tyrosine kinase

Isotype: IgG

Application Details

Application Notes: IF:1:10-1:100,IHC:1:20-1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for TXK

Target: TXK (TXK tyrosine Kinase (TXK))

Alternative Name: TXK

Background: Synonyms:TXK, Protein tyrosine kinase 4, TXK tyrosine kinase, TKL, BTKL Background:Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells(APC) activate T-cell receptor(TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells(NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1(Th1) cell-specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.

Molecular Weight: 25kDa,Observed 45kDa

Gene ID: 7294

UniProt: P42681

Pathways: Regulation of Leukocyte Mediated Immunity, Hepatitis C