MBNL3 antibody

Catalog No. ABIN5705442

This anti-MBNL3 antibody is a Rabbit Polyclonal antibody detecting MBNL3 in ELISA, WB and IHC. Suitable for Human and Mouse.

Quick Overview for MBNL3 antibody (ABIN5705442)

Target: MBNL3 (Muscleblind-Like Splicing Regulator 3 (MBNL3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBNL3 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-MBNL3 Antibody

Immunogen: muscleblind-like 3 (Drosophila)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with FNab05041( MBNL3 Antibody) at dilution of 1:600

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for MBNL3

Target: MBNL3 (Muscleblind-Like Splicing Regulator 3 (MBNL3))

Alternative Name: MBNL3

Background: Synonyms:CHCR, MBLX39, MBXL Background:Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T(TNNT2) pre-mRNA exon inclusion but induces insulin receptor(IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology(DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.

Molecular Weight: 38 kDa

Gene ID: 55796

UniProt: Q9NUK0

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development