beta Catenin antibody

Catalog No. ABIN5707937

This Rabbit Monoclonal antibody specifically detects beta Catenin in IHC (p). It exhibits reactivity toward Human.

Quick Overview for beta Catenin antibody (ABIN5707937)

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This beta Catenin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CTNNB1-2030R

Product Details anti-beta Catenin Antibody

Purification: Purified

Purity: Protein A affinity chromatography

Immunogen: Human protein was used as the immunogen for the recombinant b-Catenin antibody.

Isotype: IgG kappa

Application Details

Application Notes: Titration of the recombinant b-Catenin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. IHC (FFPE): 1-2 μg/mL,Prediluted IHC only format : incubate for 30 min at RT (1)

Restrictions: For Research Use only

Handling

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant b-Catenin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for beta Catenin

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Alternative Name: Beta Catenin

Background: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. [RefSeq]

Pathways: Peptide Hormone Metabolism