GABBR1 antibody (AA 947-961)

Catalog No. ABIN574068

This anti-GABBR1 antibody is a Goat Polyclonal antibody detecting GABBR1 in IHC and IHC (p). Suitable for Human, Rat, Mouse, Cow, Monkey, Pig, Dog, Hamster, Bat, Horse and Rabbit.

Quick Overview for GABBR1 antibody (AA 947-961) (ABIN574068)

Target: GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))

Reactivity: Human, Rat, Mouse, Cow, Monkey, Pig, Dog, Hamster, Bat, Horse, Rabbit

Host: Goat

Clonality: Polyclonal

Conjugate: This GABBR1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GABBR1 Antibody

Binding Specificity: AA 947-961

Brand: IHC-plus™

Specificity: Human GABBR1. This antibody is expected to recognize reported isoforms a, b and c (NP_001461.1, NP_068703.1, NP_068704.2 resp.).

Predicted Reactivity: Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Bat, Horse, Rabbit, Pig (100%) Phytophthora (80%).

Purification: Immunoaffinity purified

Immunogen: Synthetic peptide DRLSCDGSRVHLLYK from the C-terminus of human GABBR1 (NP_001461.1, NP_068703.1, NP_068704.2, NP_068705.2). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Bat, Horse, Rabbit, Pig (100%), Phytophthora (80%).

Type of Immunogen: Synthetic peptide

Application Details

Application Notes: Approved: IHC, IHC-P (3.75 - 5 μg/mL)

Usage: Immunohistochemistry: This antibody was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in  pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for this antibody was determined to be 3.75 to 5 μg/mL.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Tris-buffered saline,  pH 7.3, 0.5 % BSA, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Minimize freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for GABBR1

Target: GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))

Alternative Name: GABABR1 / GABBR1

Background: Name/Gene ID: GABBR1
Subfamily: GABA(B)
Family: GPCR

Synonyms: GABBR1, DJ271M21.1.1, DJ271M21.1.2, GABA(B) receptor, Gaba-b-r1a, GABA-BR1, Gaba-br1a receptor, GABAB, subunit 1c, GABAB1, GABA-B receptor 1, Gaba-b1, Gababr1 receptor, GPRC3A, Gabab-receptor subunit 1a, GABABR1, GABBR1-3, GBR1, HGB1a, GABA-B-R1, GB1

Gene ID: 2550

NCBI Accession: NP_001461, NP_068703, NP_068704, NP_068705

UniProt: Q9UBS5

Pathways: Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process