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L-Selectin antibody (PE)

This Mouse Monoclonal antibody specifically detects L-Selectin in FACS, IHC, IP and IHC (fro). It exhibits reactivity toward Human, Cow, Cynomolgus and Rhesus Monkey.
Catalog No. ABIN576304

Quick Overview for L-Selectin antibody (PE) (ABIN576304)

Target

See all L-Selectin (SELL) Antibodies
L-Selectin (SELL) (Selectin L (SELL))

Reactivity

  • 112
  • 73
  • 34
  • 18
  • 9
  • 6
  • 3
  • 2
  • 2
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  • 1
Human, Cow, Cynomolgus, Rhesus Monkey

Host

  • 93
  • 55
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  • 3
  • 1
Mouse

Clonality

  • 150
  • 51
  • 4
Monoclonal

Conjugate

  • 84
  • 24
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  • 11
  • 6
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  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This L-Selectin antibody is conjugated to PE

Application

  • 142
  • 69
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  • 39
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  • 5
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Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Specificity

    Recognizes human CD62L, also known a L-selectin, a 74-95kD member of the selectin family of adhesion receptors, which acts as a ligand for both CD62-P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes. CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of naA-ve lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains. The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation.

    Purification

    Protein G purified

    Immunogen

    PHA stimulated lymphoblasts.

    Type of Immunogen: Cells

    Isotype

    IgG2b
  • Application Notes

    Approved: Flo (1:1), IHC, IHC-Fr, IP

    Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. Flow Cytometry: Use 10 μL of the suggested working dilution to label 10^6 cells or 100 μL whole blood. Method sheets are available on request.

    Comment

    Target Species of Antibody: Human

    Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    Distilled Water.

    Concentration

    Lot specific

    Buffer

    Lyophilized, PBS,  pH 7.4, 0.09 % sodium azide, 1 % BSA.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Target

    L-Selectin (SELL) (Selectin L (SELL))

    Alternative Name

    SELL / L-Selectin / CD62L

    Target Type

    Chemical

    Background

    Name/Gene ID: SELL

    Synonyms: SELL, CD62L, CD62L antigen, LAM-1, LAM1, LECAM1, LEU8, Leukocyte adhesion molecule 1, Lyam-1, LSEL, gp90-MEL, HLHRc, PLNHR, L-selectin, Leu-8, Selectin L, LNHR, LYAM1, Lymph node homing receptor, Lymphocyte adhesion molecule 1, TQ1, Pln homing receptor

    Gene ID

    6402
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