L-Selectin antibody (PE)
Quick Overview for L-Selectin antibody (PE) (ABIN576304)
Target
See all L-Selectin (SELL) AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Specificity
- Recognizes human CD62L, also known a L-selectin, a 74-95kD member of the selectin family of adhesion receptors, which acts as a ligand for both CD62-P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes. CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of naA-ve lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains. The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation.
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Purification
- Protein G purified
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Immunogen
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PHA stimulated lymphoblasts.
Type of Immunogen: Cells -
Isotype
- IgG2b
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Application Notes
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Approved: Flo (1:1), IHC, IHC-Fr, IP
Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. Flow Cytometry: Use 10 μL of the suggested working dilution to label 10^6 cells or 100 μL whole blood. Method sheets are available on request. -
Comment
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Target Species of Antibody: Human
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Distilled Water.
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Concentration
- Lot specific
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Buffer
- Lyophilized, PBS, pH 7.4, 0.09 % sodium azide, 1 % BSA.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- L-Selectin (SELL) (Selectin L (SELL))
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Alternative Name
- SELL / L-Selectin / CD62L
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Target Type
- Chemical
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Background
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Name/Gene ID: SELL
Synonyms: SELL, CD62L, CD62L antigen, LAM-1, LAM1, LECAM1, LEU8, Leukocyte adhesion molecule 1, Lyam-1, LSEL, gp90-MEL, HLHRc, PLNHR, L-selectin, Leu-8, Selectin L, LNHR, LYAM1, Lymph node homing receptor, Lymphocyte adhesion molecule 1, TQ1, Pln homing receptor -
Gene ID
- 6402
Target
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