NBL1 antibody (AA 18-181)

Catalog No. ABIN5775893

The Mouse Monoclonal anti-NBL1 antibody (Clone AT38G8) (ABIN5775893) specifically detects NBL1 in WB, ELISA, IF, ICC and FACS. The antibody is reactive with Human samples.

Quick Overview for NBL1 antibody (AA 18-181) (ABIN5775893)

Target: NBL1 (Neuroblastoma 1, DAN Family BMP Antagonist (NBL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NBL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: AT38G8

Product Details anti-NBL1 Antibody

Binding Specificity: AA 18-181

Purpose: Human NBL1 antibody

Purification: Purified

Immunogen: Recombinant human NBL1 (18-181aa) purified from E. coli

Isotype: IgG1 kappa

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Target Details for NBL1

Target: NBL1 (Neuroblastoma 1, DAN Family BMP Antagonist (NBL1))

Alternative Name: NBL1

Background: NBL1 is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development and alternatively spliced transcript variants have been identified for this gene. Also, as a tumor suppressor gene of neuroblastoma may play an important role in preventing cells from entering the final stage (G1/S) of the transformation process. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 have been observed.

NCBI Accession: NP_005371