Layilin antibody (AA 22-235)

Catalog No. ABIN5775959

This anti-Layilin antibody is a Mouse Monoclonal antibody detecting Layilin in WB and ELISA. Suitable for Human.

Quick Overview for Layilin antibody (AA 22-235) (ABIN5775959)

Target: Layilin (LAYN)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Layilin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: AT18E10

Product Details anti-Layilin Antibody

Binding Specificity: AA 22-235

Immunogen: Recombinant human LAYN (22-235aa) purified from E. coli

Isotype: IgG1 kappa

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Target Details for Layilin

Target: Layilin (LAYN)

Alternative Name: Layilin/LAYN

Background: Layilin is a widely expressed integral membrane hyaluronan receptor and a transmembrane protein with homology to C-type lectins. This protein interacts with the ERM protein family of cytoskeletal membrane linker molecule members, including talin, ezrin, moesin, and radixin. The carboxy-terminal domain of layilin is capable of binding to the amino-terminal domain of radixin. An interdomain interaction between the amino- and the carboxy-terminal domains of radixin inhibits its ability to bind to layilin. Layilin plays an important role in cell adhesion and motility. It is important for the maintenance of the cortical structure in the cell because it mediates signals from the extracellular matrix to the cytoskeleton. In spreading cells, Layilin acts as a membrane-binding site for talin in the peripheral ruffles, and it may play a role in the migration of cells to a wound site.

NCBI Accession: NP_001245319