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BCL2L1 antibody (Thr47)

This anti-BCL2L1 antibody is a Rabbit Polyclonal antibody detecting BCL2L1 in WB, ELISA, IF and IHC (p). Suitable for Human, Mouse and Rat.
Catalog No. ABIN5959000

Quick Overview for BCL2L1 antibody (Thr47) (ABIN5959000)

Target

See all BCL2L1 Antibodies
BCL2L1 (BCL2-Like 1 (BCL2L1))

Reactivity

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Human, Mouse, Rat

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This BCL2L1 antibody is un-conjugated

Application

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Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Binding Specificity

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    Thr47

    Specificity

    Apoptosis regulator Bcl X,Apoptosis regulator Bcl-X,Apoptosis regulator BclX,B cell lymphoma 2 like,B2CL1,Bcl 2 like 1 protein,Bcl X,Bcl xL,BCL XL/S,Bcl xS,Bcl-2-like protein 1,Bcl2 Like 1,Bcl2 related gene,Bcl2-L-1,BCL2L,Bcl2l1,BCLX,BclXL,BclXs,DKFZp781P2092,PPP1R52,Protein phosphatase 1 regulatory subunit 52

    Purification

    Affinity purification

    Immunogen

    Synthesized peptide derived from human Bcl-x around the non-phosphorylation site of Thr47.

    Isotype

    IgG
  • Application Notes

    WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    BCL2L1 (BCL2-Like 1 (BCL2L1))

    Alternative Name

    BCL-x

    Background

    Bcl x is a member of the Bcl 2 family of proteins, which function as regulators of apoptosis. It may provide neuroprotection against ischemic brian injury. Bcl x has two isoforms, Bcl xl (long) a 241 amino acid protein and Bcl xs (short) a 178 amino acid protein lacking a 63 amino acid domain that is well conserved among members of the Bcl2 family. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.

    Molecular Weight

    26kDa

    Gene ID

    598

    UniProt

    Q07817

    Pathways

    Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
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