BCL2L1 antibody (Thr47)
Quick Overview for BCL2L1 antibody (Thr47) (ABIN5959000)
Target
See all BCL2L1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- Thr47
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Specificity
- Apoptosis regulator Bcl X,Apoptosis regulator Bcl-X,Apoptosis regulator BclX,B cell lymphoma 2 like,B2CL1,Bcl 2 like 1 protein,Bcl X,Bcl xL,BCL XL/S,Bcl xS,Bcl-2-like protein 1,Bcl2 Like 1,Bcl2 related gene,Bcl2-L-1,BCL2L,Bcl2l1,BCLX,BclXL,BclXs,DKFZp781P2092,PPP1R52,Protein phosphatase 1 regulatory subunit 52
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Purification
- Affinity purification
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Immunogen
- Synthesized peptide derived from human Bcl-x around the non-phosphorylation site of Thr47.
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Isotype
- IgG
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Application Notes
- WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- BCL2L1 (BCL2-Like 1 (BCL2L1))
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Alternative Name
- BCL-x
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Background
- Bcl x is a member of the Bcl 2 family of proteins, which function as regulators of apoptosis. It may provide neuroprotection against ischemic brian injury. Bcl x has two isoforms, Bcl xl (long) a 241 amino acid protein and Bcl xs (short) a 178 amino acid protein lacking a 63 amino acid domain that is well conserved among members of the Bcl2 family. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.
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Molecular Weight
- 26kDa
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Gene ID
- 598
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UniProt
- Q07817
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Pathways
- Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
Target
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