DNMT3B antibody

Catalog No. ABIN5959392

The Rabbit Polyclonal anti-DNMT3B antibody has been validated for WB, ELISA, IF and IHC (p). It is suitable to detect DNMT3B in samples from Human and Chicken.

Quick Overview for DNMT3B antibody (ABIN5959392)

Target: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Reactivity: Human, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNMT3B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-DNMT3B Antibody

Specificity: Cytosine 5methyltransferase 3B,DNA,DNA (cytosine 5) methyltransferase 3 beta,DNA (cytosine 5)-methyltransferase 3B,DNA (cytosine-5)-methyltransferase 3B,DNA methyltransferase HsaIIIB,DNA MTase HsaIIIB,DNM3B,Dnmt3b,EC 2.1.1.37,ICF,ICF1,M.HsaIIIB,MGC124407,RP23-89H14.3

Purification: Affinity purification

Immunogen: Synthesized peptide derived from the N-terminal region of human Dnmt3b

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DNMT3B

Target: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Alternative Name: Dnmt3b

Background: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.

Molecular Weight: 96kDa

Gene ID: 1789

UniProt: Q9UBC3