NEURL antibody (Tyr1248)

Catalog No. ABIN5962106

This Rabbit Polyclonal antibody specifically detects NEURL in WB, ELISA and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for NEURL antibody (Tyr1248) (ABIN5962106)

Target: NEURL (Neuralized Homolog (Drosophila) (NEURL))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NEURL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-NEURL Antibody

Binding Specificity: Tyr1248

Specificity: Verb b2 erythroblastic leukemia viral oncogene homolog 2,neuro/glioblastoma derived oncogene homolog,C erb B2/neu protein,CD340,CD340 antigen,Cerb B2/neu protein,CerbB2,Erb b2 receptor tyrosine kinase 2,ERBB2,ERBB2,HER 2,HER 2/NEU,HER2,Herstatin,Human epidermal growth factor receptor 2,Metastatic lymph node gene 19 protein,MLN 19,MLN19,NEU,NEU proto oncogene,Neuro/glioblastoma derived oncogene homolog,Neuroblastoma/glioblastoma derived oncogene homolog,NGL,p185erbB2,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Receptor tyrosine-protein kinase erbB-2,TKR1,Tyrosine kinase type cell surface receptor HER2,Tyrosine kinase-type cell surface receptor HER2,V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog),V erb b2 avian erythroblastic leukemia viral oncogene homolog 2,V erb b2 avian erythroblastic leukemia viral oncoprotein 2,V erb b2 erythroblastic leukemia viral oncogene homolog 2,neuro/glioblastoma derived oncogene homolog (avian),V erb b2 erythroblastic leukemia viral oncogene homolog 2,neuro/glioblastoma derived oncogene homolog,Verb b2 erythroblastic leukemia viral oncogene homolog 2,neuro/glioblastoma derived oncogene homolog (avian)

Purification: Affinity purification

Immunogen: Synthesized peptide derived from human Neu around the non-phosphorylation site of Tyr1248.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NEURL

Target: NEURL (Neuralized Homolog (Drosophila) (NEURL))

Alternative Name: Neu

Background: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A, the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

Molecular Weight: 138kDa

Gene ID: 2064

UniProt: P04626

Pathways: Notch Signaling, EGFR Signaling Pathway