CD70 antibody (PE)

Catalog No. ABIN610197

This anti-CD70 antibody is a Mouse Monoclonal antibody detecting CD70 in ELISA, FACS, IHC, IHC (fro), ICC and Func. Suitable for Human. This Primary Antibody has been cited in 2+ publications.

Quick Overview for CD70 antibody (PE) (ABIN610197)

Target: CD70 (CD70 Molecule (CD70))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD70 antibody is conjugated to PE

Application: ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Functional Studies (Func)

Clone: BU69

Product Details anti-CD70 Antibody (PE)

Specificity: CD70 Molecule of approximately 30 kd.

Purification: Gel filtration

Immunogen: Human WM-1 (Waldenstrpm's macroglobulinemia) cell line.

Isotype: IgG1

Application Details

Application Notes: Approved: ELISA, Flo, Func, ICC, IHC, IHC-Fr

Usage: Function: Blocks the interaction between CD27 and CD70, and has been shown to inhibit T cell proliferation induced by dendritic cells. One test is 1.6 μL per 5 x 10e5 cells. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 50 mM sodium phosphate,  pH 7.5, 500 mM potassium chloride, 150 mM sodium chloride, 15 % Glycerol, 0.2 % BSA, 0.04 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze. Product is photosensitive and should be protected from light.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze. Protect from light.

References for anti-CD70 antibody (PE) (ABIN610197)

MacLaren, Clark, Gillespie: "v-Jun sensitizes cells to apoptosis by a mechanism involving mitochondrial cytochrome C release." in: Oncogene, Vol. 19, Issue 51, pp. 5906-18, (2000) (PubMed).

Arnold, Seifert, Asadullah, Volk: "Crosstalk between keratinocytes and T lymphocytes via Fas/Fas ligand interaction: modulation by cytokines." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 12, pp. 7140-7, (1999) (PubMed).

Target Details for CD70

Target: CD70 (CD70 Molecule (CD70))

Alternative Name: CD70

Background: Name/Gene ID: CD70
Family: TNF

Synonyms: CD70, CD27LG, Ki-24 antigen, Surface antigen CD70, CD27 ligand, CD27-L, CD70 antigen, CD70 Molecule, TNFSF7

Gene ID: 970

UniProt: P32970

Pathways: Cancer Immune Checkpoints