CD70 antibody

Catalog No. ABIN610198

This Mouse Monoclonal antibody specifically detects CD70 in ELISA, FACS, IHC, IHC (fro), ICC and Func. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for CD70 antibody (ABIN610198)

Target: CD70 (CD70 Molecule (CD70))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD70 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Functional Studies (Func)

Clone: BU69

Product Details anti-CD70 Antibody

Specificity: CD70 Molecule of approximately 30 kd.

Purification: Protein A purified

Immunogen: Human WM-1 (Waldenstrpm's macroglobulinemia) cell line.

Isotype: IgG1

Application Details

Application Notes: Approved: ELISA, Flo, Func, ICC, IHC, IHC-Fr

Usage: Function: Blocks the interaction between CD27 and CD70, and has been shown to inhibit T cell proliferation induced by dendritic cells. The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 50 mM sodium phosphate,  pH 7.5, 100 mM potassium chloride, 150 mM sodium chloride

Preservative: Azide free

Handling Advice: Do not freeze. Open under aseptic conditions.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze. Open under aseptic conditions.

References for anti-CD70 antibody (ABIN610198)

MacLaren, Clark, Gillespie: "v-Jun sensitizes cells to apoptosis by a mechanism involving mitochondrial cytochrome C release." in: Oncogene, Vol. 19, Issue 51, pp. 5906-18, (2000) (PubMed).

Arnold, Seifert, Asadullah, Volk: "Crosstalk between keratinocytes and T lymphocytes via Fas/Fas ligand interaction: modulation by cytokines." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 12, pp. 7140-7, (1999) (PubMed).

Target Details for CD70

Target: CD70 (CD70 Molecule (CD70))

Alternative Name: CD70

Background: Name/Gene ID: CD70
Family: TNF

Synonyms: CD70, CD27LG, Ki-24 antigen, Surface antigen CD70, CD27 ligand, CD27-L, CD70 antigen, CD70 Molecule, TNFSF7

Gene ID: 970

UniProt: P32970

Pathways: Cancer Immune Checkpoints