ACLY antibody (pSer455)

Catalog No. ABIN6136002

This Rabbit Polyclonal antibody specifically detects ACLY in WB, IHC and IP. It exhibits reactivity toward Human.

Quick Overview for ACLY antibody (pSer455) (ABIN6136002)

Target: ACLY (ATP Citrate Lyase (ACLY))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACLY antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-ACLY Antibody

Binding Specificity: pSer455

Sequence: TASFS

Cross-Reactivity: Mouse, Rat

Characteristics: Phosphorylated Antibodies

Purification: Affinity purification

Immunogen: A synthetic phosphorylated peptide around S455 of human ACLY (NP_001087.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IP,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ACLY

Target: ACLY (ATP Citrate Lyase (ACLY))

Alternative Name: ACLY

Background: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene.,ACLY,ACL,ATPCL,CLATP,Cancer,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,Insulin Receptor Signaling Pathway,Warburg Effect,Protein phosphorylation,ACLY

Molecular Weight: 91 kDa/119 kDa/120 kDa

Gene ID: 47

UniProt: P53396

Pathways: Warburg Effect