ABCG5 antibody (AA 350-450)

Catalog No. ABIN6136383

The Rabbit Polyclonal anti-ABCG5 antibody has been validated for WB. It is suitable to detect ABCG5 in samples from Human.

Quick Overview for ABCG5 antibody (AA 350-450) (ABIN6136383)

Target: ABCG5 (ATP-Binding Cassette, Sub-Family G (WHITE), Member 5 (ABCG5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCG5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ABCG5 Antibody

Binding Specificity: AA 350-450

Sequence: TLPMVPFKTK DSPGVFSKLG VLLRRVTRNL VRNKLAVITR LLQNLIMGLF LLFFVLRVRS NVLKGAIQDR VGLLYQFVGA TPYTGMLNAV NLFPVLRAVS D

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 350-450 of human ABCG5 (NP_071881.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ABCG5

Target: ABCG5 (ATP-Binding Cassette, Sub-Family G (WHITE), Member 5 (ABCG5))

Alternative Name: ABCG5

Background: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia.,ABCG5,STSL,Cancer,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Cardiovascular,Heart,Lipids,Cardiovascular diseases,Heart disease,ABCG5

Molecular Weight: 28 kDa/72 kDa

Gene ID: 64240

UniProt: Q9H222

Pathways: Lipid Metabolism