Activin A Receptor Type IB/ALK-4 antibody (AA 24-126)

Catalog No. ABIN6136505

The Rabbit Polyclonal anti-Activin A Receptor Type IB/ALK-4 antibody has been validated for WB. It is suitable to detect Activin A Receptor Type IB/ALK-4 in samples from Human. There is 1 publication available.

Quick Overview for Activin A Receptor Type IB/ALK-4 antibody (AA 24-126) (ABIN6136505)

Target: Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Activin A Receptor Type IB/ALK-4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Activin A Receptor Type IB/ALK-4 Antibody

Binding Specificity: AA 24-126

Sequence: SGPRGVQALL CACTSCLQAN YTCETDGACM VSIFNLDGME HHVRTCIPKV ELVPAGKPFY CLSSEDLRNT HCCYTDYCNR IDLRVPSGHL KEPEHPSMWG PVE

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 24-126 of human ACVR1B (NP_004293.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-Activin A Receptor Type IB/ALK-4 antibody (ABIN6136505)

Dong, Liu, Meng, Liu, Bi, Wu, Jin, Yao, Tang, Wang, Li, Zhang, Yu, Zhan, Chen, Ge, Yang, Li: "Keratin 8 limits TLR-triggered inflammatory responses through inhibiting TRAF6 polyubiquitination." in: Scientific reports, Vol. 6, pp. 32710, (2018) (PubMed).

Target Details for Activin A Receptor Type IB/ALK-4

Target: Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))

Alternative Name: ACVR1B

Background: This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.,ACVR1B,ACTRIB,ACVRLK4,ALK4,SKR2,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Cytoskeleton,Microfilaments,Stem Cells,ACVR1B

Molecular Weight: 51 kDa/53 kDa/54 kDa/56 kDa/61 kDa

Gene ID: 91

UniProt: P36896