ATP2B4 antibody (AA 1141-1205)

Catalog No. ABIN6137320

Product Details anti-ATP2B4 Antibody

Target: ATP2B4 (ATPase, Ca++ Transporting, Plasma Membrane 4 (ATP2B4))

Binding Specificity: AA 1141-1205

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP2B4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ELPRTPLLDE EEEENPDKAS KFGTRVLLLD GEVTPYANTN NNAVDCNQVQ LPQSDSSLQS LETSV

Cross-Reactivity: Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1141-1205 of human ATP2B4 (NP_001675.3).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:4000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ATP2B4

Target: ATP2B4 (ATPase, Ca++ Transporting, Plasma Membrane 4 (ATP2B4))

Alternative Name: ATP2B4 (ATP2B4 Products)

Background: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.,ATP2B4,ATP2B2,MXRA1,PMCA4,PMCA4b,PMCA4x,Cancer,Signal Transduction,Endocrine & Metabolism,Neuroscience,Calcium Signaling,ATP2B4

Molecular Weight: 124-137 kDa

Gene ID: 493

UniProt: P23634

Pathways: Ribonucleoside Biosynthetic Process