Antizyme Inhibitor 1 antibody (AA 289-448)

Catalog No. ABIN6137388

This Rabbit Polyclonal antibody specifically detects Antizyme Inhibitor 1 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for Antizyme Inhibitor 1 antibody (AA 289-448) (ABIN6137388)

Target: Antizyme Inhibitor 1 (AZIN1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Antizyme Inhibitor 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Antizyme Inhibitor 1 Antibody

Binding Specificity: AA 289-448

Sequence: AKKVVENDKF PSGVEKTGSD EPAFMYYMND GVYGSFASKL SEDLNTIPEV HKKYKEDEPL FTSSLWGPSC DELDQIVESC LLPELNVGDW LIFDNMGADS FHEPSAFNDF QRPAIYYMMS FSDWYEMQDA GITSDSMMKN FFFVPSCIQL SQEDSFSAEA

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 289-448 of human AZIN1 (NP_056962.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Antizyme Inhibitor 1

Target: Antizyme Inhibitor 1 (AZIN1)

Alternative Name: AZIN1

Background: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine, however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene.,AZIN1,AZI,AZI1,AZIA1,OAZI,OAZIN,ODC1L,Signal Transduction,Endocrine & Metabolism,Amino acid metabolism,AZIN1

Molecular Weight: 49 kDa

Gene ID: 51582

UniProt: O14977