C8orf4 antibody (AA 1-106)

Catalog No. ABIN6137787

This anti-C8orf4 antibody is a Rabbit Polyclonal antibody detecting C8orf4 in WB and IHC. Suitable for Human.

Quick Overview for C8orf4 antibody (AA 1-106) (ABIN6137787)

Target: C8orf4 (Chromosome 8 Open Reading Frame 4 (C8orf4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C8orf4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-C8orf4 Antibody

Binding Specificity: AA 1-106

Sequence: MKAKRSHQAI IMSTSLRVSP SIHGYHFDTA SRKKAVGNIF ENTDQESLER LFRNSGDKKA EERAKIIFAI DQDVEEKTRA LMALKKRTKD KLFQFLKLRK YSIKVH

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-106 of human C8orf4 (NP_064515.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for C8orf4

Target: C8orf4 (Chromosome 8 Open Reading Frame 4 (C8orf4))

Alternative Name: C8orf4

Background: This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.,C8orf4,TC-1,TC1,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Apoptosis,Stem Cells,C8orf4

Molecular Weight: 12 kDa

Gene ID: 56892

UniProt: Q9NR00