Calmodulin 2 antibody (AA 1-149)

Catalog No. ABIN6137872

This anti-Calmodulin 2 antibody is a Rabbit Polyclonal antibody detecting Calmodulin 2 in WB. Suitable for Human.

Quick Overview for Calmodulin 2 antibody (AA 1-149) (ABIN6137872)

Target: Calmodulin 2 (Calm2) (Calmodulin 2 (phosphorylase Kinase, Delta) (Calm2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calmodulin 2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Calmodulin 2 Antibody

Binding Specificity: AA 1-149

Sequence: MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-149 of human CALM2 (NP_001734.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Calmodulin 2

Target: Calmodulin 2 (Calm2) (Calmodulin 2 (phosphorylase Kinase, Delta) (Calm2))

Alternative Name: CALM2

Background: This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms.,CALM2,CAMII,LQT15,PHKD,PHKD2,caM,Signal Transduction,Kinase,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Cytoskeleton,Actins,Immunology & Inflammation,B Cell Receptor Signaling Pathway,T Cell Receptor Signaling Pathway,Neuroscience,Neurodegenerative Diseases,CALM2

Molecular Weight: 17 kDa

Gene ID: 805

UniProt: P62158

Pathways: RTK Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Cellular Glucan Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, Phototransduction, Negative Regulation of Transporter Activity, VEGFR1 Specific Signals, BCR Signaling