Caspase 2 antibody (AA 153-452)

Catalog No. ABIN6137960

The Rabbit Polyclonal anti-Caspase 2 antibody has been validated for WB. It is suitable to detect Caspase 2 in samples from Human.

Quick Overview for Caspase 2 antibody (AA 153-452) (ABIN6137960)

Target: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Caspase 2 Antibody

Binding Specificity: AA 153-452

Sequence: KLRLSTDTVE HSLDNKDGPV CLQVKPCTPE FYQTHFQLAY RLQSRPRGLA LVLSNVHFTG EKELEFRSGG DVDHSTLVTL FKLLGYDVHV LCDQTAQEMQ EKLQNFAQLP AHRVTDSCIV ALLSHGVEGA IYGVDGKLLQ LQEVFQLFDN ANCPSLQNKP KMFFIQACRG DETDRGVDQQ DGKNHAGSPG CEESDAGKEK LPKMRLPTRS DMICGYACLK GTAAMRNTKR GSWYIEALAQ VFSERACDMH VADMLVKVNA LIKDREGYAP GTEFHRCKEM SEYCSTLCRH LYLFPGHPPT

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 153-452 of human Caspase-2 (NP_116764.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Caspase 2

Target: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Alternative Name: CASP2

Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.,CASP2,CASP-2,ICH1,NEDD-2,NEDD2,PPP1R57,caspase-2,Cancer,Invasion and Metastasis,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Caspases,Mitochondrial Control of Apoptosis,Ubiquitin,Endocrine & Metabolism,Immunology & Inflammation,CASP2

Molecular Weight: 10 kDa/34 kDa/50 kDa

Gene ID: 835

UniProt: P42575

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway