COL1A1 antibody (AA 100-200)

Catalog No. ABIN6138837

This Rabbit Polyclonal antibody specifically detects COL1A1 in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for COL1A1 antibody (AA 100-200) (ABIN6138837)

Target: COL1A1 (Collagen, Type I, alpha 1 (COL1A1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COL1A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-COL1A1 Antibody

Binding Specificity: AA 100-200

Sequence: ESPTDQETTG VEGPKGDTGP RGPRGPAGPP GRDGIPGQPG LPGPPGPPGP PGPPGLGGNF APQLSYGYDE KSTGGISVPG PMGPSGPRGL PGPPGAPGPQ G

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human COL1A1 (NP_000079.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for COL1A1

Target: COL1A1 (Collagen, Type I, alpha 1 (COL1A1))

Alternative Name: COL1A1

Background: This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.,COL1A1,EDSC,OI1,OI2,OI3,OI4,COL1A1

Molecular Weight: 138 kDa

Gene ID: 1277

UniProt: P02452

Pathways: Sensory Perception of Sound, Autophagy, Growth Factor Binding