COL4A1 antibody (AA 1445-1669)

Catalog No. ABIN6138841

This anti-COL4A1 antibody is a Rabbit Polyclonal antibody detecting COL4A1 in WB. Suitable for Human.

Quick Overview for COL4A1 antibody (AA 1445-1669) (ABIN6138841)

Target: COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COL4A1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-COL4A1 Antibody

Binding Specificity: AA 1445-1669

Sequence: GFLVTRHSQT IDDPQCPSGT KILYHGYSLL YVQGNERAHG QDLGTAGSCL RKFSTMPFLF CNINNVCNFA SRNDYSYWLS TPEPMPMSMA PITGENIRPF ISRCAVCEAP AMVMAVHSQT IQIPPCPSGW SSLWIGYSFV MHTSAGAEGS GQALASPGSC LEEFRSAPFI ECHGRGTCNY YANAYSFWLA TIERSEMFKK PTPSTLKAGE LRTHVSRCQV CMRRT

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1445-1669 of human COL4A1 (NP_001836.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for COL4A1

Target: COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))

Alternative Name: COL4A1

Background: This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants.,COL4A1,BSVD,RATOR,Stem Cells,COL4A1

Molecular Weight: 127 kDa/160 kDa

Gene ID: 1282

UniProt: P02462

Pathways: Skeletal Muscle Fiber Development, Growth Factor Binding