desert Hedgehog antibody (AA 199-396)

Catalog No. ABIN6139585

This Rabbit Polyclonal antibody specifically detects desert Hedgehog in WB. It exhibits reactivity toward Human.

Quick Overview for desert Hedgehog antibody (AA 199-396) (ABIN6139585)

Target: desert Hedgehog (DHH) (Desert Hedgehog (DHH))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This desert Hedgehog antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-desert Hedgehog Antibody

Binding Specificity: AA 199-396

Sequence: CFPGNATVRL WSGERKGLRE LHRGDWVLAA DASGRVVPTP VLLFLDRDLQ RRASFVAVET EWPPRKLLLT PWHLVFAARG PAPAPGDFAP VFARRLRAGD SVLAPGGDAL RPARVARVAR EEAVGVFAPL TAHGTLLVND VLASCYAVLE SHQWAHRAFA PLRLLHALGA LLPGGAVQPT GMHWYSRLLY RLAEELLG

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 199-396 of human DHH (NP_066382.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for desert Hedgehog

Target: desert Hedgehog (DHH) (Desert Hedgehog (DHH))

Alternative Name: DHH

Target Type: Species

Background: This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development.,DHH,GDXYM,HHG-3,SRXY7,Cell Biology & Developmental Biology,Hedgehog Signaling Pathway,Stem Cells,DHH

Molecular Weight: 43 kDa

Gene ID: 50846

UniProt: O43323

Pathways: Hedgehog Signaling