Desmocollin 1 antibody (AA 480-690)

Catalog No. ABIN6139825

The Rabbit Polyclonal anti-Desmocollin 1 antibody has been validated for WB. It is suitable to detect Desmocollin 1 in samples from Human.

Quick Overview for Desmocollin 1 antibody (AA 480-690) (ABIN6139825)

Target: Desmocollin 1 (DSC1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmocollin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Desmocollin 1 Antibody

Binding Specificity: AA 480-690

Sequence: SQDGFPAGQE LLGYKALDPE ISSGEGLRYQ KLGDEDNWFE INQHTGDLRT LKVLDRESKF VKNNQYNISV VAVDAVGRSC TGTLVVHLDD YNDHAPQIDK EVTICQNNED FAVLKPVDPD GPENGPPFQF FLDNSASKNW NIEEKDGKTA ILRQRQNLDY NYYSVPIQIK DRHGLVATHM LTVRVCDCST PSECRMKDKS TRDVRPNVIL G

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 480-690 of human DSC1 (NP_077739.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Desmocollin 1

Target: Desmocollin 1 (DSC1)

Alternative Name: DSC1

Background: The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein.,DSC1,CDHF1,DG2/DG3,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cadherins,Cytoskeleton,Extracellular Matrix,DSC1

Molecular Weight: 93 kDa/99 kDa

Gene ID: 1823

UniProt: Q08554