DUOX1 antibody (AA 1312-1551)

Catalog No. ABIN6139857

The Rabbit Polyclonal anti-DUOX1 antibody has been validated for WB. It is suitable to detect DUOX1 in samples from Human.

Quick Overview for DUOX1 antibody (AA 1312-1551) (ABIN6139857)

Target: DUOX1 (Dual Oxidase 1 (DUOX1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUOX1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DUOX1 Antibody

Binding Specificity: AA 1312-1551

Sequence: ALGTTEYHPF TLTSAPHEDT LSLHIRAAGP WTTRLREIYS APTGDRCARY PKLYLDGPFG EGHQEWHKFE VSVLVGGGIG VTPFASILKD LVFKSSVSCQ VFCKKIYFIW VTRTQRQFEW LADIIREVEE NDHQDLVSVH IYITQLAEKF DLRTTMLYIC ERHFQKVLNR SLFTGLRSIT HFGRPPFEPF FNSLQEVHPQ VRKIGVFSCG PPGMTKNVEK ACQLINRQDR THFSHHYENF

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1312-1551 of human DUOX1 (NP_059130.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DUOX1

Target: DUOX1 (Dual Oxidase 1 (DUOX1))

Alternative Name: DUOX1

Background: The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.,DUOX1,LNOX1,NOXEF1,THOX1,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,Neuroscience,DUOX1

Molecular Weight: 137 kDa/177 kDa

Gene ID: 53905

UniProt: Q9NRD9