DUOX1 antibody (N-Term)

Catalog No. ABIN5514730

The Rabbit Polyclonal anti-DUOX1 antibody is suitable to detect DUOX1 in samples from Human. It has been validated for WB.

Quick Overview for DUOX1 antibody (N-Term) (ABIN5514730)

Target: DUOX1 (Dual Oxidase 1 (DUOX1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUOX1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DUOX1 Antibody

Binding Specificity: N-Term

Purpose: DUOX1 Antibody - N-terminal region

Sequence: LLVGAWTPLG AQNPISWEVQ RFDGWYNNLM EHRWGSKGSR LQRLVPASYA

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DUOX1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP80953-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for DUOX1

Target: DUOX1 (Dual Oxidase 1 (DUOX1))

Alternative Name: DUOX1

Background:

Background Information: The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.

Gene Name: dual oxidase 1

Alternative Symbols: LNOX1, THOX1, NOXEF1

Protein Name: dual oxidase 1

Molecular Weight: 170 kDa

Gene ID: 53905

NCBI Accession: NP_059130

UniProt: Q9NRD9