EP400 antibody (AA 90-330)

Catalog No. ABIN6140195

The Rabbit Polyclonal anti-EP400 antibody has been validated for WB. It is suitable to detect EP400 in samples from Human.

Quick Overview for EP400 antibody (AA 90-330) (ABIN6140195)

Target: EP400 (E1A Binding Protein P400 (EP400))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EP400 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-EP400 Antibody

Binding Specificity: AA 90-330

Sequence: TLAPLPLPSP TSPGFQFSAQ PRRFEHGSPS YIQVTSPLSQ QVQTQSPTQP SPGPGQALQN VRAGAPGPGL GLCSSSPTGG FVDASVLVRQ ISLSPSSGGH FVFQDGSGLT QIAQGAQVQL QHPGTPITVR ERRPSQPHTQ SGGTIHHLGP QSPAAAGGAG LQPLASPSHI TTANLPPQIS SIIQGQLVQQ QQVLQGPPLP RPLGFERTPG VLLPGAGGAA GFGMTSPPPP TSPSRTAVPP G

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 90-330 of human EP400 (NP_056224.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:1000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for EP400

Target: EP400 (E1A Binding Protein P400 (EP400))

Alternative Name: EP400

Background: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.,EP400,CAGH32,P400,TNRC12,Epigenetics & Nuclear Signaling,Chromatin Remodeling,EP400

Molecular Weight: 331 kDa/335 kDa/339 kDa/343 kDa

Gene ID: 57634

UniProt: Q96L91

Pathways: Chromatin Binding